Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
نویسندگان
چکیده
منابع مشابه
Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity.
RATIONALE Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart. The recent discovery that the transcriptional coactivator Yes-associated protein (Yap) is necessary and sufficient for cardiomyocyte proliferation has gained considerable attention. However, the upstream regulators and si...
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A dult mammalian cardiomyocytes possess little endoge-nous proliferative capacity. This innate limitation underlies our inability to reverse heart failure and improve patient outcome after myocardial injury. The mechanisms that restrict adult mammalian cardiomyocyte proliferation have been the intensely scrutinized, and molecular insights are slowly emerging. 1 In this issue of Circulation Rese...
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RATIONALE Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets ...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature22979